allergic reaction (hypersensitivity or allergy), autoimmune reaction and adverse immune stimulation.
If the conventional toxicity study indicates the existence of immunotoxicity, the appropriate additional immunotoxicity test method should be decided according to the nature of the observed immunological changes and the types of compounds. The immune system is very sensitive to exogenous substances, so it is necessary to selectively study some tested substances, especially the poisons whose target organs are the immune system.
Immunotoxicity Studies Provided by Prisys
Generally speaking, immunotoxicity test methods that have been widely used and have proved to be sensitive and specific to known immunosuppressants should be selected. For many drugs, the immunotoxicity of non-human primates is a strongly recommended option. With years of efforts, Prisys developed a world-leading preclinical experiment platform, and completed the immunotoxicity research experiments of hundreds of candidate drugs for many customers around the world. We have an experienced team of over 10 years, which can not only provide suggestions for research design, but also provide extensive in vitro and in vivo immunotoxicological analysis. Include:
- Hematology and clinical biochemistry
- Gross pathology and organ weight
- Histopathological examination
- Explanation of stress-related changes
- MTD, dose-ranging tests
- Single-dose toxicity test
- Repeated Dosing Toxicity Test
- Allergy test
- Hemolytic test
- Local irritation test
- In vivo phototoxicity test
- www.prisysbiotech.com
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